Happy Birthday to Project MK-ULTRA!

 From Wikipedia:

Project MK-ULTRA, or MKULTRA, was the code name for a covert CIA mind-control and chemical interrogation research program, run by the Office of Scientific Intelligence. The program began in the early 1950s, continuing at least through the late 1960s, and it used United States citizens as its test subjects. The published evidence indicates that Project MK-ULTRA involved the surreptitious use of many types of drugs, as well as other methods, to manipulate individual mental states and to alter brain function.

Headed by Dr. Sidney Gottlieb, the MK-ULTRA project was started on the order of CIA director Allen Dulles on April 13, 1953, largely in response to Soviet, Chinese, and North Korean use of mind-control techniques on U.S. prisoners of war in Korea. The CIA wanted to use similar methods on their own captives. The CIA was also interested in being able to manipulate foreign leaders with such techniques, and would later invent several schemes to drug Fidel Castro.

Experiments included administering LSD to CIA employees, military personnel, doctors, other government agents, prostitutes, mentally ill patients, and members of the general public in order to study their reactions. LSD and other drugs were usually administered without the subject's knowledge and informed consent, a violation of the Nuremberg Code that the U.S. agreed to follow after World War II.

Efforts to "recruit" subjects were often illegal, even discounting the fact that drugs were being administered (though actual use of LSD, for example, was legal in the United States until October 6, 1966). In Operation Midnight Climax, the CIA set up several brothels to obtain a selection of men who would be too embarrassed to talk about the events. The men were dosed with LSD, and the brothels were equipped with one-way mirrors and the "sessions" were filmed for later viewing and study.
Some subjects' participation was consensual, and in many of these cases, the subjects appeared to be singled out for even more extreme experiments. In one case, volunteers were given LSD for 77 consecutive days.

Another technique investigated was connecting a barbiturate IV into one arm and an amphetamine IV into the other. The barbiturates were released into the subject first, and as soon as the subject began to fall asleep, the amphetamines were released. The subject would begin babbling incoherently at this point, and it was sometimes possible to ask questions and get useful answers.
Other experiments involved heroin, morphine, temazepam (used under code name MK-SEARCH), mescaline, psilocybin, scopolamine, marijuana, alcohol, and sodium pentothal.

 Forty-four American colleges or universities, 15 research foundations or chemical or pharmaceutical companies and the like including Sandoz (currently Novartis) and Eli Lilly & Co., 12 hospitals or clinics (in addition to those associated with universities), and 3 prisons are known to have participated in MK-ULTRA.

A considerable amount of credible circumstantial evidence suggests that Theodore Kaczynski, also known as the Unabomber, participated in CIA-sponsored MK-ULTRA experiments conducted at Harvard University from the fall of 1959 through the spring of 1962. During World War II, Henry Murray, the lead researcher in the Harvard experiments, served with the Office of Strategic Services (OSS), which was a forerunner of the CIA. Murray applied for a grant funded by the United States Navy, and his Harvard stress experiments strongly resembled those run by the OSS. Beginning at the age of sixteen, Kaczynski participated along with twenty-one other undergraduate students in the Harvard experiments, which have been described as "disturbing" and "ethically indefensible."

Merry Prankster Ken Kesey, author of One Flew Over the Cuckoo's Nest, volunteered for MK-ULTRA experiments while he was a student at Stanford University. Kesey's ingestion of LSD during these experiments led directly to his widespread promotion of the drug and the subsequent development of hippie culture.

Because most MK-ULTRA records were deliberately destroyed in 1973 by order of then CIA Director Richard Helms, it has been difficult, if not impossible, for investigators to gain a complete understanding of the more than 150 individually funded research sub-projects sponsored by MK-ULTRA and related CIA programs.